Publications

KRAS: Biology, Inhibition, and Mechanisms of Inhibitor Resistance

Current Oncology. April 3, 2024.

Ash LA, Busia-Bourdain O, Okpattah D, Kamel A, Liberchuk A, and Wolfe AL.

Targeting cancer’s sweet spot: UGP2 as a therapeutic vulnerability

Molecular and Cellular Oncology. October 27, 2021.

Kim S, Wolfe AL*, Kim SE*

UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth

Proceedings of the National Academy of Sciences of the United States of America. August 3, 2021.

Wolfe AL, Zhou Q, Toska E, Galeas J, Ku AA, Koche RP, Bandyopadhyay S, Scaltriti M, Lebrilla CB, McCormick F*, Kim SE*

NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer

Communications Biology. March 9, 2021.

Pappas K, Martin TC, Wolfe AL, Nguyen CB, Su T, Jin J, Hibshoosh H, Parsons R

NRF2 Activation Confers Resistance to eIF4A Inhibitors in Cancer Therapy

Cancers. February 5, 2021.

Sanghvi VR, Mohan P, Singh K, Cao L, Berishaj M, Wolfe AL, Schatz JH, Lailler N, de Stanchina E, Viale A, Wendel HG

Cystic Fibrosis Transmembrane Conductance Regulator Attaches Tumor Suppressor PTEN to the Membrane and Promotes Anti Pseudomonas aeruginosa Immunity

Immunity. December 19, 2017.

Riquelme SA, Hopkins BD, Wolfe AL, DiMango E, Kitur K, Parsons R, Prince A

Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia

Science Signaling. November 18, 2014.

Sanghvi VR, Mavrakis KJ, Van der Meulen J, Boice M, Wolfe AL, Carty M, Mohan P, Rondou P, Socci ND, Benoit Y, Taghon T, Van Vlierberghe P, Leslie CS, Speleman F, Wendel HG

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

Nature. September 4, 2014.

Wolfe AL*, Singh K*, Zhong Y, Drewe P, Rajasekhar VK, Sanghvi VR, Mavrakis KJ, Jiang M, Roderick JE, Van der Meulen J, Schatz JH, Rodrigo CM, Zhao C, Rondou P, de Stanchina E, Teruya-Feldstein J, Kelliher MA, Speleman F, Porco JA Jr, Pelletier J, Rätsch G, Wendel HG

The Eph-receptor A7 is a soluble tumor suppressor for follicular lymphoma

Cell. October 28, 2011

Oricchio E, Nanjangud G, Wolfe AL, Schatz JH, Mavrakis KJ, Jiang M, Liu X, Bruno J, Heguy A, Olshen AB, Socci ND, Teruya-Feldstein J, Weis-Garcia F, Tam W, Shaknovich R, Melnick A, Himanen JP, Chaganti RS, Wendel HG

Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma

Journal of Experimental Medicine. August 29, 2011.

Schatz JH, Oricchio E, Wolfe AL, Jiang M, Linkov I, Maragulia J, Shi W, Zhang Z, Rajasekhar VK, Pagano NC, Porco JA Jr, Teruya-Feldstein J, Rosen N, Zelenetz AD, Pelletier J, Wendel HG

A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)

Nature Genetics. June 5, 2011.

Mavrakis KJ, Van Der Meulen J, Wolfe AL, Liu X, Mets E, Taghon T, Khan AA, Setty M, Rondou P, Vandenberghe P, Delabesse E, Benoit Y, Socci NB, Leslie CS, Van Vlierberghe P, Speleman F, Wendel HG

Mouse models of cancer as biological filters for complex genomic data

Disease Models and Mechanisms. Nov-Dec 2010.

Oricchio E, Wolfe AL, Schatz JH, Mavrakis KJ, Wendel HG

Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia

Nature Cell Biology. February 28, 2010.

Mavrakis KJ*, Wolfe AL*, Oricchio E, Palomero T, de Keersmaecker K, McJunkin K, Zuber J, James T, Khan AA, Leslie CS, Parker JS, Paddison PJ, Tam W, Ferrando A, Wendel HG

*Denotes equal authorship contribution.