Why do so many cancers recur after seemingly successful treatment? How can understanding the biology of oncogenes lead to new therapeutic possibilities?
 
The Wolfe lab strives to gain a deeper understanding of how tumors depend on driver oncogenes to reprogram their growth, metabolism, and survival signals. Understanding mechanisms by which pancreatic cancers, lung cancers, and colorectal cancers develop resistance to targeted therapies is instrumental to developing innovative approaches that can improve patient outcomes.
 
The lab employs techniques related to molecular biology, pharmacology, biochemistry, cancer signaling, tissue culture, large-scale screening, models of cancer, flow cytometry, CRISPR, and more.